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Adhesives and sealants are effective because they address the "root cause" of mechanical failure; the innter space between components. Inner space includes the clearance that exists between threaded assemblies, in the unfilled space in press fits, and in the surface imperfections between flanges. Machinery adhesives solve the problem of mechanical failures caused by the clearance between close-fitting parts in assemblies by filling this space with a thermoset plastic engineered to provide predictable properties of adhesion, elongation, and environmental resistance.
In general they are not required. Anaerobic materials cure by reacting with the surface of active metal like steel, cast iron or brass. However if the gaps are large (exceed 0.005”) the primer is useful to ensure the anaerobic materials cure.
The root cause of fastener loosening, pipe and gasket leakage and bearing loosening is inner space between components. In order for parts to fit together designers have to leave clearance space. Once assembled, this space is no longer required and the source of issues. Anaerobic materials fill this inner space stopping leaks and vibration loosening.